Background: Dermatoglyphics is the branch of science that deals with the study of ridge patterns on finger tips, palm, sole and toes and when once formed, they remain unchanged throughout the except after severe injuries. These patterns can serve as a non-invasive, cost-effective tool which can be used for the prediction of cancer. This can also serve as a baseline guide to identify women with breast cancer. Objective: To study the digital dermatoglyphic patterns among women with breast cancer in comparison with normal individuals. Materials and methods: 50 female patients with breast cancer of age group between 30-70 years were compared with 50 control group of individuals with no history of cancer. The breast cancer patients and the control group were of the same age and sex. Digital dermatoglyphic patterns were taken among these individuals with the aid of a dermatoglyphic kit. Procedure involved was modified purvis smith method. Results: digital dermatoglyphic patterns were analyzed between the patients and control group of individuals which showed statistical difference. Conclusion: we conclude that there is a genetic influence on the dermatoglyphic patterns. With the aid of this, the occurrence of breast cancer can be predicted and this dermatoglyphics can serve as a non-invasive, anatomical marker and a predictor tool to determine the individuals with breast cancer.