Abstract

Investigation of adsorption kinetic of Doxorubicin onto iron oxide magnetic nanoparticles functionalized with poly(acrylic acid)/Allyl Alchohol

Author(s):Fatemeh Siami, Homayon Ahmadpanahi, Amir Heidarinasab, Elham Moniri, Azim Akbarzadeh and Hasan Ebrahimi Shahmabadi

The study aimed to prepare iron oxide magnetic nanoparticles(MNPs) loaded with anticancer drug Doxorubicin (DOX) in order to evaluate the adsorption isotherms and adsorption kinetic of particles. Nanoparticles were prepared by a reduction–precipitation method and coated with poly(acrylic acid)/Allyl Alchohol as a pH-sensitive co-polymer followed by loading with DOX. They were characterized by FTIR, XRD and TEM techniques. Shapely nanoparticles with the size of 27 nm and loading efficiency of 90% were produced. Also it was cleared that DOX adsorption onto MMNP follows pseudo first-order kinetics. Finally, the proper results of study suggested evaluating the efficacy of nanoparticles against a cancer cell line in vitro environment.

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