Objectives: To evaluate the pattern of use of Antimicrobial drugs in IPD patients admitted for various illnesses. Materials and Methods: It is a retrospective and observational study, conducted during the period of January, 2011 to December, 2011. Prescription record of 252 patients admitted in IPD of Medicine & Surgery departments of the PDVVPFs Medical College & Hospital, Ahmednagar were studied. These data were obtained from Medical Record Departmeent (MRD) of the hospital. The study was conducted after obtaining permission from the Institutional Ethics Committee (IEC) of the college. Data were analyzed for- average number of antimicrobials prescribed per prescription, the relationship between patient age and sex, percentage usage of various antimicrobial groups and percentage use of individual antimicrobials. Results: It was observed that 75 % of patients were prescribed 1-2 antimicrobial agent and 25 % were prescribed 3 or more than 3 antimicrobials. Cephalosporins were the most preferred antimicrobials followed by quinolones and aminoglycosides. Fluconazole was found to be most commonly prescribed antifungal whereas Artesunate and Metronidazole were most preferred antimalarial and antiamoebic drugs. Conclusion: It can be concluded from the present study that physicians preferred to prescribe 2 or more than 2 antibacterial agents in a prescription. To treat various infections Cephalosporins and quinolones were observed to be most prescribed antibacterials. Fluconazole, Artesunate & Metronidazole were found to be commonly prescribed antifungal, antimalarial and antiamoebic agents. Uses of Macrolides, Tetracyclines & Vancomycin were very low. However, aminoglycosides were commonly prescribed to young males and Cepahalosporins to young female patients.