Gastrointestinal stromal tumor (GIST) is categorized as a mesenchymal tumor. In the abdomen more than half occur in the stomach. Adenocarcinoma is the most common epithelial malignancy of stomach comprising over 90% of all gastric cancers. The simultaneous occurrence of both these tumors together is rare. This is an interesting case report of a 54 year old lady with synchronous occurrence of GIST and poorly differentiated adenocarcinoma of intestinal type. A brief review of literature is done regarding the reported cases and proposed hypothesis.