Background: Epilepsy is a serious neurological disorder that affects 50 million people worldwide. Conventional antiepileptic drugs are coupled with several adverse effects and contraindications. Herbal agents that possess antiepileptic potential could be a better alternative to conventional medicine with minimal or no adverse effects. Aims and objectives: The aim of this study was to evaluate the antiepileptic effects of a combined herbal extract of Brassica nigra and Swertia chirata, in comparison with standard drugs in pentylenetetrazole model of seizure. Methodology: Wistar albino rats (weighing 180-220 gram) were randomly divided into 6 groups having 6 animals in each group. Group 1: Control (DMSO 10%, 10 ml/kg b.w, p.o), Group 2: Diazepam 10 mg/kg, p.o; Group 3: Valproic acid 300 mg/kg, p.o; Group 4: Brassica nigra (BN) 250 mg/kg and Swertia chirata (SC) 250 mg/kg, p.o; Group 5: BN 250 mg/kg and SC 500 mg/kg p.o; Group 6: BN 500 mg/kg and SC 250 mg/kg p.o. Results: In the pentylenetetrazole model; Group 4, significantly delayed the onset (p=0.01) and duration of seizures (p=0.003) as compared to control. In Group 5, the onset of seizure was significantly delayed (p=0.000, p=0.01) as compared to control and diazepam respectively; while the duration of seizure was increased (p=0.003) as compared to valproic acid. In Group 6; the onset of seizure was significantly delayed (p=0.000, 0.000) as compared to control and diazepam; whereas, duration of seizure was significantly decreased (p=0.007) as compared to control. Conclusion: On the basis of these results, we can conclude that the herbal combinations possess anti-seizure potential.