Abstract

REGENERATION OF ARTICULAR CARTILAGE UNDER THE IMPLANTATION OF BONE MATRIX

Author(s):Yuri M. Iryanov, Nikolay A. Kiryanov, Olga V. Dyuriagina, Tatiana Yu. Karaseva, Evgenii A. Karasev

Background: The amage or loss of articular cartilage is costly medical problem. The purpose of this work - morphological analysis of reparative chondrogenesis when implanted in the area of the knee joint cartilage of granulated mineralized bone matrix. Material and Methods: The characteristic features of the knee cartilage regeneration studied experimentally in pubertal Wistar rats after modeling a marginal perforated defect and implantation of granulated mineralized bone matrix obtained according to original technology without heat and demineralizing processing into the injury zone. Results: This biomaterial established to have pronounced chondro- and osteoinductive properties, and to provide prolonged activation of reparative process, accelerated organotypical remodeling and restoration of the articular cartilage injured. Conclusion: The data obtained demonstrate the efficacy of ÐÂ�?�??�?�?ÐÂ�?�??�?�??ÐÂ�?�??�?�? in clinical practice for the treatment of diseases and injuries of the articular cartilage.

• PDF