International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)
Balasubramaniyan Vairappan
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, IndiaPublications
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Research Article
The Utility of STRIATIN as A Novel Diagnostic Marker in Cirrhosis
Author(s): Vigneshwaran Venkatesan, Balasubramaniyan Vairappan* and Pazhanivel Mohan
Aim: Endothelial dysfunction and associated endothelial Nitric Oxide Synthase (eNOS) mediated reduction in Nitric Oxide (NO) bioavailability has been implicated in the development of Portal Hypertension (PHT) in cirrhosis. However, the role of striatin, a key protein involved in the activation of the eNOS signaling pathway, remains largely unexplored in cirrhosis. Here, we aimed to study the hepatic expression of striatin and its connotation with eNOS in cirrhosis. Also, the systemic concentration of striatin in cirrhotic patients and to determine its potential as a diagnostic marker for cirrhotic patients with Portal Hypertension (PHT). Materials and methods: This case-control study includes 40 cirrhotic patients and 40 healthy volunteers (control subjects). Hepatic striatin and phosphorylated eNOS (peNOS) expression were studied using west.. Read More»
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