Background: Small scars have been linked to bad psychosocial outcomes emphasizing the necessity of wound healing treatments that are successful. According to burn clinicians, there is a strong link between scar formation and the time it takes to re-epithelialize, especially in children. The major goal of burn wound healing is to speed up the healing and closure process. Aim: The current research aimed to examine the effects of Silver sulfadiazine, and topical Sucralfate in the treatment of second-degree superficial burn wound healing. Methods: The study enrolled 80 patients of both sex under the age group of 30 years with 50 percent second-degree superficial burns. Patients were evenly split into two groups. Patients in group A received topical sucralfate dressing, whereas those in group B received 1% Silver sulfadiazine dressing. The patients’ demographics, history, physical, and systemic examinations were all documented and for the detailed analysis, SPSS 20.0 was employed. Results: Granulation emerged in 20 (50%) of patients in less than a week, while in group B, granulation appeared between 15 and 20 days in 22 (55%) of patients (p=0.134). The average day of granulation in group A was 8.12 ± 1.96 days compared to 8.94 ± 3.69 days in group B (p=0.392). On days 1, 7, and 14, the wound culture was performed. Conclusion: Topical sucralfate dressing is more effective than silver sulfadiazine dressing in terms of promoting early granulation in the healing of second-degree superficial burns, but its antibacterial activity is equivalent to silver sulfadiazine dressing. To reinforce the notion, multicentric experiments with larger sample sizes are required.