Molluscum contagiosum is a viral disease caused by mollusci pox virus (DNA virus).Seen commonly as disease in children and immunocompromised adults. Infection transmitted by direct skin to skin contact, fomites or sexual contact. A 27 year old male with pearly umblicated skin coloured papules and nodules over whole face with history of weight loss (10 kg in 3 months) along with history of sexual contact. On investigation HIV ELISA was positive and biopsy report showing Henderson Peterson bodies, conforming molluscum contagiosum. Patient was diagnosed as MCV in HIV. Patient was treated with HAART and topical imiquimod 5% cream and he responded well to treatment.