Patients with chronic liver diseases are asymptomatic or have only vague non-specific symptoms. Effective medical treatments for chronic liver disease (before cirrhosis is established) are becoming increasingly available and since abnormal LFTs may be the only indication of these diseases. Aims: Enzymes study of various liver diseases. Discussion: serum Alkaline phosphatase (ALP), Gamma Glutamyl transferase (Gamma GT), Alanine and Aspartate amino transferases were estimated in viral Hepatitis, Alcoholic liver diseases, Obstructive jaundice, cirrhosis of the liver. It was observed that obstructive jaundice shows higher levels of ALP levels followed by alcoholic liver disease, viral hepatitis, cirrhosis of the liver. Viral hepatitis shows higher rise of SGOT, SGPT levels, followed by alcoholic liver disease, obstructive jaundice, and cirrhosis of the liver. Gamma Glutamyl transferase enzymes highest levels are seen in alcoholic liver disease. Conclusion: These enzymatic variations are useful to diagnose the disease and classify them according to etiology.