Intake of polyphenols, probiotics, and multivitamins has shown beneficial effects on spatial memory, learning, and cognition. However, the effect of various combinations of these nutrients as dietary intake on cognitive performance has remained unexamined. Knowing which antioxidant combination would be most effective is important, especially because regular intake of all nutraceuticals may not be possible. This study examined the best combination of nutrients that enhances spatial memory and cognitive performance. Since quality of nutrition can have a significant effect on memory and learning, the outcome of this study could be significant to improving cognitive function in humans, particularly in the context of childhood education. Especially with current disparities leading to food deserts and differing access to quality food, this may reveal changes to make in mass nutrition to better support cognitive performance and learning.