This study was conducted in 2015 with goal of analysis of the effects of a support program based on psychosocial needs of families on care burdens of family caregivers of patients with ischemic heart disease hospitalized in Chamran heart ward of Isfahan University of Medical Sciences. This study in terms of purpose is functional and in terms of data gathering is Field survey. The population of this study consisted of 64 patients with ischemic heart disease (32 people in experimental group and 32 people in control group) who were referred to inner heart wards of Chamran hospital. Data collection tools were 2 questionnaires; Psychosocial Needs Assessment questionnaire and Care Burden questionnaire. Results of study showed that in the control group the mean score of the Care burdens was a significant difference between three times (p< 0.05). Apart from the physical realm there was no significant difference observed between control groups. The results showed that immediately after the intervention (p<0/001) and one month after intervention (p<0.001) the average score of the overall Care burdens and areas of (physical, emotional, social, developmental and time) in control group was significantly higher than experimental group and there was a significant difference between the two groups. The results also showed that findings revealed that before intervention, there was no significant difference between the two experimental and control groups in average of overall Care burdens and areas of (physical, emotional, social, developmental and time) of caregivers of patients with ischemic heart disease.