Background and objectives: Caregivers of children experiencing mental health challenges reporting negative physical and emotional effects due to the lack of recognition and support. This study is aimed to explore the burden on caregivers of children with Attention deficit hyperactivity disorder (ADHD) in Medina. Subjects and methods: A cross-sectional study was conducted in the child psychiatric and developmental and behavioral clinics at Maternity and the children hospital (MMCH) and child psychiatric clinic at AlAmal hospital for mental health in Medina among 80 caregivers. The validated Arabic version of ZBI scale was distributed to 80 participants. T test and ANOVA test were performed to assess the association between sociodemographic variables and ZBI scale. Results: The age of participants ranged between 20 and 60 years. Females represent most of them (66.2%). Moderate to severe and severe burden on caregivers of children with ADHD were observed among 43.8% and 18.8% of the participants, respectively. Gender of the caregiver of was significantly associated with burden of care giving as score of ZBI was significantly higher in females compared to males (47.3 ± 16.5 versus 39.3 ± 16.8), p=0.045. Conclusion: Burden on caregivers of children with ADHD in Medina was very high prevalent, particularly among female caregivers.