Medical prescriptions are bound to be misinterpreted by patients and pharmacists if not properly conveyed. Pediatric prescriptions differ from adult prescriptions having wide variation in doses and formulations.There is a need to evaluate the lacunae in the parental understanding of pediatric prescriptions.Aims and objective: To evaluate the parental understanding ofpediatric prescription and to evaluate the adequacy of communication with the physician and pharmacist regarding the same.Material and methods: 550 parents were enrolled and their literacy level was noted.They were subjected to modify MUSE questionnaire.Physician’s prescription was analyzed in terms of ease of understanding by parents. These parents were followed up till the pharmaciesand the pharmacist understanding of prescription was analyzed and their communication with parents regarding drug usage was noted. Finally, ease of usage of drugs by parents was noted. Results:MUSE scale was modified to suit pediatric prescription understanding by parents and also additional questions were asked to include complete parental understanding of doctor’s prescription. Majority of parents failed to completely understand the written prescription. Though around 80% of pharmacist could understand the prescription, their communication with parents was poor resulting in difficulty for parents to even enquire about medicines from them. Parental overall understanding of prescription increased with their literacy levels. Conclusion:Not all prescriptions are completely understood by parents as well as a pharmacist. This can lead to misuse of drugs. Efforts to explain the drug usage are not adequate enough from the doctor or the pharmacist. While communicating literacy levels of parents is not being considered which may further worsen the understanding ability.