International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)

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Assessment of Salivary Interleukin-1 Receptor Antagonist and Obesity Measures of Patients with Chronic Periodontitis in Comparison to Healthy Control

Author(s):Ali Baidaa T, Mahmood Maha SH

Aim: To measure BMI and waist circumference (WC) of patients with chronic periodontitis as well as healthy control, and to correlate these measurements with the clinical periodontal parameters, also to assess the level of salivary IL-1Ra of patients with chronic periodontitis in comparison to healthy control, to correlate the level of this marker with the clinical periodontal parameters and with anthropometric measurements (BMI and WC). Materials and Methods: Ninety subjects including both males and females with age between 35-55 years participated in this study. They were divided into two groups: Group 1 was chronic periodontitis (CP) group and it consist of 55 subjects and the Group 2 consist of 35 subjects as control group as they were with healthy periodontium and systemically healthy. Anthropometric measurements were measured for all participants, the whole unstimulated salivary sample was collected, and then periodontal evaluation that including the assessment of clinical periodontal parameters were done for all participants. ELISA was used to determine the level of IL-1Ra in saliva. Results: The results revealed a nonsignificant difference between the two groups regarding the BMI, while showed that there was a significant difference in WC between the two groups, that the mean value of WC was higher in chronic periodontitis group than the control group. Regarding the salivary level of IL-1Ra it was revealed that the mean value of salivary level of IL-1Ra was statistically higher in chronic periodontitis group than the control group and there was a highly significant difference between them. According to Pearson Correlation, this study showed that there is a strong positive correlation between clinical periodontal parameters (GI, BOP, PPD, and CAL) with BMI and WC. This study also revealed that there is a strong positive correlation between clinical periodontal parameters with salivary level of IL-1Ra. Also, it showed a strong positive correlation between salivary level of IL-1Ra with BMI and WC. Conclusion: This study offers evidence of relationship between clinical periodontal and obesity parameters therefore one condition may act as a risk factor for another as well as it showed relationship between salivary IL-1Ra and periodontal/obesity measures.

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