Objective: The purpose of this study was to appraise the association between Physical Activity and T2DM, hypertension, hypercholesterolemia, and other comorbidities in a series of Saudi volunteers. Methodology: The present study investigated 304 healthy Saudi volunteers for reported chronic illness and the status of physical activity. Results: Out of the 144 individuals, 62/144 (43%) were males and 82/144 (57%) were females. About 64/304 (21%), 75/304 (24.7%), and 21/304 (7%) of the participants practicing physical activity for one hour, 2-5 hours, and ≥ 6 hours, in this order. Conclusion: PA rates are relatively lower among Saudi people in Northern Saudi Arabia. PA was found to be an effective factor in reducing diverse comorbidities including hypertension, T2DM, hypercholesterolemia, CVDs, asthma, and other comorbidities.