Background: Gastroesophageal reflux disease (GERD) has become the most frequently seen gastrointestinal disorder in outpatient clinics. The esophageal mucosal epithelium will be affected by gastric acidity due to the altered gastroesophageal junction. Aim of the study: To examine the association between circulating levels of adiponectin and GERD among patients undergoing upper endoscopy. Type of the study: A case-control study. Patients and methods: A planned study by Al-Kindy College of Medicine, done from January 2017 to May 2018. Data were collected from 40 GERD patients and 30 healthy control individuals and endoscopy were done for them. Their weight, height, waist circumference, body mass index was calculated. Lipid profile and adiponectin were done for them. Results: The results showed that there was a strong negative correlation between adiponectin and age, height, weight, BMI, waist circumference, waist to hip ratio, cholesterol, triglyceride, LDL. There is only a positive correlation between adiponectin and HDL and LDL/HDL (+0.214 and +0.014 respectively). Conclusions: This present study highlights that derangement of circulating adiponectin gut hormones is involved in the pathogenesis of GERD and may predispose to Barrett’s esophagus.