Aim of the study is to evaluate children taking orthodontic treatment with chronic congenital systemic disorders, and hurdle to orthodontic treatment plan and treatment mechanic during and before orthodontic treatment. Sum of 317 articles were collected from EBSCO, MEDKNOW, OVID MEDILINER, SCOPUS, ELSEVIER AND SAGE, abstract and citation database was collected qualitative articles were selected. 79 full-text articles were reviewed, and met inclusion criteria. Many of the articles have been proposed the following are the features of systemic disorder and orthodontic treatment: Cardiac disease, Hematological disease, Respiratory disease, neural disease, Endocrine disease and renal disease. Orthodontic treatment is elective treatment procedure not compulsive, hence can be successfully carried out with compromised orthodontic objectives.