The incidence of physical mobility impairment and pain that caused by excess of uric acid in the joints is on the increase. Uric acid is a product of purine metabolism that tends to occur in the elderly but now is common in younger men and women. The purpose of this activity is to prevent the excess of uric acid, complaint of pain and maximize the quality of life independently through Posyandu cadres optimizing. This is a health intervention to improve the knowledge and skills of cadres and the elderly in the Gunung Lurah Village, Banyumas through lectures, discussions, practice, technology transfer and mentoring of uric acid examination. Implementation method consists of problem identification, formulating intervention, and implementation of cadre empowerment and mentoring package. Pre and post data were analyzed quantitatively. The results showed that there were significant differences in the ability of cadres in managing gout. Cadres can apply their knowledge and skills in empowering elderly to reduce pain and prevent gout. The empowerment package model of cadres and elderly is effective in reducing pain and preventing the incidence of gout in rural area.