Background: Chronic kidney disease (CKD) is becoming a major health problem among the elder population in the Hail region, Saudi Arabia. In this present study, our aim was to screen the usage of herbal products in comparison to the non-steroidal anti-inflammatory analgesic (NSAIAs) usage in Hail population (apparently normal) in Saudi Arabia (KSA) and their possible impact on chronic kidney disease (CKD). Methodology: A multi-centre crosssectional study was carried out with an apparently normal sample population of Hail. The sample was collected from different provinces of Hail region (Al-Zahra, Sidian, Sharaf, Alwesitaa, Lubda, Nasia, Nugra, Samra). The sample was analyzed under group five criteria i.e., based on Hail region, based on gender, based on age, based on creatinine level, and based on the education level, which was evaluated for the screening of drugs usage with reference to chronic kidney disease. The sample population was exposed to two types of drugs, non-steroidal anti-inflammatory drugs (NSAIDs) and herbal products with reference to CKD. Results: The results drawn from the statistical analysis were tabulated. The screening of drugs (analgesics and herbal) on selected groups from a total population of Hail region proved that more herbal products are used than analgesics drugs. Traditional herbal preparation usage was indicated in 216/4565 (12.182%) samples and NSAIAs usage was revealed in 156/4565 (8.798%) samples. Conclusion: The use of traditional herbal therapy and NSAIAs is prevalent in Hail region and it is more apparent among less educated individuals. Traditional herbal therapy proves to be more used than analgesics. The regular use of herbal products and non-steroidal anti-inflammatory drugs (NSAIDs) for a long period may increase the risk of CKD progression.