Background: Propofol is the most commonly used intravenous inducing agent. Sharp, burning, or aching pain on injection is a major problem. The cardiovascular response to the pain can aggravate adverse events in patients with a history of coronary artery disease Small boluses of ketamine, magnesium, dexmedetomidine, ondansetron, dexamethasone, lignocaine hydrochloride, ketorolac, metoclopramide, and opioids have been tried. Objectives: To compare analgesic effects of using intravenous ketamine and lignocaine in alleviating pain following propofol injection. Methods: A prospective randomized double-blinded study was conducted in Chettinad Hospital and Research Institute, Kelambakkam among 50 participants undergoing surgeries under general anaesthesia . Tourniquet was applied midarm, Group L was given 21.3 mg of 2% lignocaine and Group K was given 15mg of ketamine. Tourniquet was removed after 30 seconds and then 1/3rd dose of a total dose of 2 mg/kg propofol was given. The degree of injection pain was evaluated using the Mccririck Hunter scale. Results: The pain score on propofol injection was similar in both groups. Among the patients, 54% reported no pain, in that 76% of patients were in Group L and 52% of patients in Group K. Mccririck and hunter pain scale ratings between the two groups are similar with a p-value of more than 0.05. Conclusions: The pre-treatment of 15 mg ketamine is as effective as 21.3 mg 2% lignocaine in reducing the severity of propofol injection pain.
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