The fatigue defined as lack ability of a person to produce required power or the inability to maintain and duration the generated power for doing targeted activity. The effect of fatigue in creating sport injuries and consequently treatment costs, staying away from sport as well as reducing the quality of athletic performance is evidence for everyone. Research that has been done in the field of fatigue have had an overall overview of this issue. The objective of this research was doing a comparison the effect of body and lower limbs fatigue on the performance and risk factors of lower limbs in the women novice athletes. In this study, 45 novice female athletes were selected as available. A pre-test including functional tests and the test of landing error without applying body fatigue protocol And lower limbs were done from the subjects and after a day resting in the second day after applying ABT fatigue protocol in the body fatigue group and Bosko fatigue protocol in the lower limbs group the functional tests and landing error was done. Kolmogorov-Smirnov, ANOVA and Kruskal-Wallis tests in the 0.05 significance used for data statistical analysis. Results indicated that the fatigue of body and lower limbs leads to increase significance and risky factors of lower limbs injuries and reducing significance of dynamic balance in all directions. Also there was not observed a meaningful difference between average changes in risk factors for lower extremity injuries, dynamic balance (in all directions) on invoice women of body fatigue group and lower limbs. The body and lower limbs fatigue leads to reduce dynamic balance and increasing risk factors of lower limbs.