Introduction: Functional status assessment in patients suffering with Chronic Obstructive Pulmonary Disease (COPD) is the essential component and Six-Minute Walk Test (6MWT) is a valid tool for it. The amount of physical activity possible in patients with chronic obstructive pulmonary disease (COPD) predicts exacerbations, hospital admissions, and mortality. Therefore, guidelines advocate the need to entitle improved physical activity status as a major target of treatment in such patients. Objective: To determine the correlation of sit to stand test with 6-minute walk test in patients with chronic obstructive pulmonary disease. Methodology: An analytical cross-sectional study was done in Chest Medicine department, Jinnah hospital, Karachi during 2015-16. A total of 100 patients with mildto-severe COPD were included in this study. The STST and 6MW Test was performed and compared with each other and with COPD Assessment Test (CAT). Results: Overall 100 patients were recruited for the study with mild-tosevere chronic obstructive pulmonary disease. The mean age of the patients was 60.50 ± 7.03 years. On applying the Correlation coefficient test, a moderate positive correlation was found between Sit to stand test and 6-minute walk test distance (r=0.71, p=0.0005). Mild positive correlation was also found in these patients between the Sit to stand test and chronic obstructive pulmonary disease Assessment Test score (STST and CAT r=0.46, p=0.011). Similarly, moderate positive correlation was found between 6-minute walk test distance and chronic obstructive pulmonary disease Assessment Test score (r=0.58, p=0.001). Conclusion: It is concluded that in COPD patients, the functional capacity can be assessed through STST instead of 6 MW Test having the same results.