Objective: Diabetes mellitus is one of the chronic diseases that carry a lot of complications on patients. This disease is not at a curable condition, but by medications can minimize or retard the occurrence of such complication. Diabetes patients need to be followed continuously to control any disease development. This follow up is done through monitoring blood glucose level, glycated hemoglobin, lipid profile, macro-vascular complications (cardiovascular complications), microvascular complications (neuropathy, nephropathy, and retinopathy) and schedule a physical examination to control any development. Methods: In this study, 106 patients were involved. About 61 female and 45 male participated in the study. Mean age was 35.1 ± 16.65 for diabetes mellitus type 1 and 53.37 ± 11.4 for diabetes mellitus type 2. Their body mass index was 23.9 ± 5.84 for diabetes type 1 and 31.17 ± 6.54 for type 2. Estimation of lifestyle (healthy diet and exercise) and type of medications, study their effect on complications (neuropathy, blurred vision, decrease body weight) and the incidences are studied. Results: In this study, as the good lifestyle was maintained it was observed that there was a decrease in the incidence of diabetic complications; glycated hemoglobin shows decrease in its value if the patient follows good lifestyle. Also, a combination of medications (metformin+glibenclamide) gives better result on complication incidence than metformin alone and on the level of glycated hemoglobin. Conclusion: Good lifestyle, choosing good medication (especially combination medications) and continuous follow up to give a good prognosis and maintain a good level of health for diabetic patients.