GET THE APP

Detection of Lymphocyte Subsets and Inflammatory Cytokines in Mild and Severe COVID-19 Patients | Abstract
Logo

(IJMRHS)
Indexed in: ESCI (Thomson Reuters)

Abstract

Detection of Lymphocyte Subsets and Inflammatory Cytokines in Mild and Severe COVID-19 Patients

Author(s):Samah M Fathy* and Mona I Ahmed

Background and objectives: The pandemic Coronavirus Disease 2019 (COVID-19) is the most threatening infectious disease nowadays that affecting people’s health worldwide. The disease symptoms were attributed to infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The current article aimed to discriminate different lymphocyte subtypes and pro-inflammatory mediators in COVID-19 patients with an emphasis on variations in their levels in mild and severely infected individuals that might help in the disease early intervention. Subjects and methods: The count of the Cluster of Differentiation (CD)3+ T, CD4+ T, CD8+ T cells, B lymphocytes, and Natural Killer (NK) cells were measured in the blood of healthy control and COVID-19 people with mild and severe symptoms using a flow cytometer. The plasma levels of Nuclear Factor kappa B (NF-κB), Tumor Necrosis Factor-α (TNF-α), Interleukin (IL)-6, IL-1β, IL-8, Procalcitonin (PCT), and Platelet-Activating Factor (PAF) were also detected by Enzyme-Linked Immunosorbent Assay (ELISA). Results: Total lymphocyte count and lymphocyte subsets significantly decreased in the blood of COVID-19 patients with more decrements in severely infected patients. The inflammatory markers levels remarkably increased in COVID-19 patients with higher increments in severe COVID-19 infected patients. Conclusion: In conclusion, the reduced level of the lymphocyte subsets and the induced pro-inflammatory response were vital signs that were concomitant with COVID-19. Besides, they were associated with the severity of the disease.


Select your language of interest to view the total content in your interested language

Archive
Scope Categories
  • Clinical Research
  • Epidemiology
  • Oncology
  • Biomedicine
  • Dentistry
  • Medical Education
  • Physiotherapy
  • Pulmonology
  • Nephrology
  • Gynaecology
  • Dermatology
  • Dermatoepidemiology
  • Otorhinolaryngology
  • Ophthalmology
  • Sexology
  • Osteology
  • Kinesiology
  • Neuroscience
  • Haematology
  • Psychology
  • Paediatrics
  • Angiology/Vascular Medicine
  • Critical care Medicine
  • Cardiology
  • Endocrinology
  • Gastroenterology
  • Infectious Diseases and Vaccinology
  • Hepatology
  • Geriatric Medicine
  • Bariatrics
  • Pharmacy and Nursing
  • Pharmacognosy and Phytochemistry
  • Radiobiology
  • Pharmacology
  • Toxicology
  • Clinical immunology
  • Clinical and Hospital Pharmacy
  • Cell Biology
  • Genomics and Proteomics
  • Pharmacogenomics
  • Bioinformatics and Biotechnology