The present study was carried out to explore the relationship between organizational commitment and personality trait of nursing managers in the selected hospitals in Isfahan province in 2015. It is descriptive-correlation from methodological aspect and applicable from objective aspect. The statistical population included nursing managers of the selected hospitals in Isfahan province in 2015. Questionnaire (containing two sections) was tool of data collection which was consisted of 84 questions based on the Likert five-option scale. Cronbach's alpha coefficient was used to calculate reliability of the questionnaire that was obtained equal to 0.903 for managers' personality trait questionnaire and 0.957 for organizational commitment questionnaire. Data analysis was carried out at descriptive and inferential statistics levels via SPSS 21 software. The obtained results disclosed that there is a significant relationship between organizational commitment and personality trait of nursing managers in the selected hospitals in Isfahan province given the correlation coefficient. In choosing nursing managers, components of personality trait such as extraversion, agreeableness, openness to experience, and dutifulness should be considered to enhance job commitment and improve hospital service offering.