Delirium is one of the common problems of cognitive impairment after coronary artery bypass graft surgery (CABG) that its prevention, timely detection, and treatment require a care and management program to be controlled. The present research has studied a care program for the management of delirium in patients after coronary artery bypass graft surgery. This research was performed by action research methodology during a fivestage cycle in two groups of 50 persons (without interference and with intervention). In both groups, the patients were evaluated every 8 hours by CAM-ICU tool in hours (6, 14 and 22) for the occurrence of delirium after surgery until they were in Intensive Care Unit (ICU). In the intervention group, the developed program was implemented in three areas of delirium management before, during, and after the surgery. Then, the collected information was analyzed in two groups using descriptive and analytical statistics in SPSS 20 software. Delirium was observed at least once in 68% of patients without the intervention and 38% of patients with intervention after surgery. The ratio of delirium incidence was significantly lower in the intervention group (P<0.05). In addition, the total number of delirium in ICU was significantly lower for patients in the intervention group (P<0.05).The developed program for reducing the incidence of delirium in hospitalized patients after coronary artery bypass graft surgery (CABG) was confirmed. This means that its applying will lead to a reduction in delirium.