GET THE APP

Diagnostic Value of Mean Platelets Volume in Ankylosing Spondylitis as a Predictor of Disease Activity | Abstract
Logo

International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)

Abstract

Diagnostic Value of Mean Platelets Volume in Ankylosing Spondylitis as a Predictor of Disease Activity

Author(s):Faiq I. Gorial

Background: Ankylosing spondylitis (AS) is a chronic progressive inflammatory rheumatic disease that leads to significant decrease in the quality of life. Mean platelet volume (MPV) is a part of the complete blood count (CBC) test and correlates with the platelets function and activation. Objective: To evaluate the diagnostic value of MPV in patients with AS and to assess its relationships with disease activity index. Patients and Methods: A total of 100 patients with AS (78 males: 22 females) were diagnosed according to the modified New York classification criteria for AS and 146 (99male: 47 female) healthy individuals were matched in age and sex as controls. Demographic data, disease activity scores using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), medical history, C-reactive protein (CRP), erythrocytes sedimentation rate (ESR), and MPV were measured. Results: Mean age of patients was 38.0 ± 9.0 years and controls were 35.8 ± 8.3 years. Males were 78% in patients and 67.8% in controls. The mean BMI was 28.3 ± 5.5 kg/m2 in patients and 28.6 ± 3.8 kg/m2 in controls. There were no statistically significant differences in age, sex, and BMI between patients and controls (p>0.05). MPV was significantly higher in patients with AS compared to healthy controls (9.215 ± 1.57 vs. 7.753 ± 0.86). MPV had a good ability to differentiate between active AS and inactive AS patients. Optimum cut off point was less than 9.9. MPV had the highest accuracy (79%) with high specificity 86.8 %, positive predictive value (PPV) at pretest 50% was 84.9%, and at pretest, 90% was 98.1% with sensitivity 74.2% and negative predictive value (NPV) at pretest 10% was 96.8%. MPV had a significant positive correlation with disease activity. Increased MPV will increase disease activity. Conclusion: MPV was significantly higher in AS patients than in controls and directly correlated with ESR, CRP, and BASDAI.


Select your language of interest to view the total content in your interested language

Archive
Scope Categories
  • Clinical Research
  • Epidemiology
  • Oncology
  • Biomedicine
  • Dentistry
  • Medical Education
  • Physiotherapy
  • Pulmonology
  • Nephrology
  • Gynaecology
  • Dermatology
  • Dermatoepidemiology
  • Otorhinolaryngology
  • Ophthalmology
  • Sexology
  • Osteology
  • Kinesiology
  • Neuroscience
  • Haematology
  • Psychology
  • Paediatrics
  • Angiology/Vascular Medicine
  • Critical care Medicine
  • Cardiology
  • Endocrinology
  • Gastroenterology
  • Infectious Diseases and Vaccinology
  • Hepatology
  • Geriatric Medicine
  • Bariatrics
  • Pharmacy and Nursing
  • Pharmacognosy and Phytochemistry
  • Radiobiology
  • Pharmacology
  • Toxicology
  • Clinical immunology
  • Clinical and Hospital Pharmacy
  • Cell Biology
  • Genomics and Proteomics
  • Pharmacogenomics
  • Bioinformatics and Biotechnology