The present research explored the differences in perceived quality of life of adolescents afflicted with End stage renal disease (ESRD)/ renal failure with reference to different dialysis modality. It was hypothesized that there would be significant differences in the reported quality of life of the patients of end stage renal disease that are going through either hemodialysis or peritoneal dialysis. Employing ex-post facto research design and nonprobability purposive sampling technique, a sample of (n=70) patients with renal failure was accessed from various hospitals. Quality of life was measured through the Pediatric Inventory of Quality of Life (PedsQL™ Version 4.0) Core Scales, while Dialysis Symptom Index and Brief Cope were also employed. The results revealed that the patients with peritoneal dialysis (PD) indicated greater quality of life than hemodialysis patients (HD) while Aggravated dialysis symptoms emerged as strong predictors of poorer quality of life among adolescents. The impact of the event scale reflected that there were greater scores for the patients with PD than the patients with HD, revealing that life situations are construed as more impact oriented by the adolescents going through PD. The current findings provide direction to health professionals to work on spreading awareness to parents and professional community about significance of raising quality of life of adolescence, afflicted with ESRD. The results carry significant implication for health professionals to envision the devising of effective strategies for improving the quality of life of Adolescents with ESRD.