Background: This study examined the response of kinesio taping (KT) in combination with the conventional occupational therapy as compared to conventional occupational therapy alone on motion, pain with functional performance and subsequent quality of life in subjects having subacromial impingement syndrome (SIS) across 30. Methods: Total 30 subjects of SIS (15 in each group) were allocated in Group 1 (Control) having only conventional therapy and Group 2 (Experiment) with both Kinesio Taping and conventional therapy. Used all KT in the study was (5 cm) beige Kinesio Tex tape with different colours. Dosage of intervention: 5 days in a week for 4 weeks (that includes 15 minutes in application of KT followed by 30 minutes rest, subsequently 40 minutes engagement in activity). Outcomes: Goniometer for range of motion, PENN shoulder score for pain with functional performance, SF-12 for Quality of life. These all were applied on day zero (pre-test) and after 4th week (post-test) data. Results: Group 2 yielded significant improvement than Group 1 in ROM, PENN shoulder score, & Sf-12 QOL at post treatment with value p<0.05. Conclusion: The current study has shown that kinesio taping in combination with the conventional occupational therapy provides improvement in ROM, functional performance and quality of life in subjects with subacromial impingement syndrome than the conventional occupational therapy alone; which proves our hypotheses.