Abstract

Effect of Methanol Extract of Swertia chirata on Various Cellular Components of Blood in Rats

Author(s):Muneeza Lodhi, Zahida Memon, Shehla Shaheen and Ambreen Wasim

Background: Swertia chirata has been used for its medicinal purpose worldwide specifically in developing countries. People believe that medicinal plants are safe and economical; However, unaware of their toxic effects. Hematological parameters are the essential tool to assess the degree of toxicity on cellular components of blood. Objective: The aim of this study is to evaluate the effect of Swertia chirata on hematological parameters in rats using an automated analyser. Methodology: Albino Wistar rats were randomly assigned into three groups of six rats each. Group 1 was control, while group 2 (LD) and group 3 (HD) received 250 mg/kg and 500 mg/kg body weight of extract respectively, orally once daily. Results: No significant difference was observed in the WBC count of extract treated groups(P>0.05). The HD group did not show any significant difference (P>0.05) in the RBC count, HCT, Hb, MCV, MCH, MCHC, RDW, platelet count, PDW, MPV, PLCR as compared to control and LD groups. Whereas, MCHC was decreased in the LD group (P<0.0001; P<0.05) as compared to the control and high dose groups respectively. The RDW in the LD group was significantly increased (P<0.005) as compared to the control group. The P-LCR and PDW of the LD group were significantly decreased (P<0.05) as compared to the control and HD groups. Conclusion: The oral administration of Swertia chirata at low dose increases RDW and decreases MCHC, P-LCR and PDW, while no significant difference was observed at high dose on different haematological parameters.

• PDF