The main complaint most often experienced patients with Chronic Obstructive Pulmonary Disease (COPD) it was packed. One nursing interventions to increase confidence in the efforts to overcome the shortness of the COPD patient self-efficacy pursed lip breathing. This study aims to determine the effect of self-efficacy pursed lip breathing to decrease tightness and increased oxygen saturation of patients with COPD. The study design was a randomized controlled trial to study design pretest-posttest design. The study involved 36 respondents using block randomization technique respondents are divided into 18 intervention and 18 control group respondents. The results of statistical analysis showed that there were significant differences decrease tightness and increased oxygen saturation between the intervention and control groups after the intervention, with p <0.001. Self efficacy pursed lip breathing can be used as an alternative airway management nursing intervention in COPD patients.