Introduction: Hand grip strength is a widely used test in experimental and epidemiological studies. The measure of hand grip strength is influenced by several factors, including age; gender; different angle of the shoulder, elbow, forearm, and wrist; and posture. So we planned to study the effect of slow voluntary breathing exercise (Savitri Pranayam) on the various strengths of isometric hand grip (IHG) among young health care students. Methods: The present study was conducted on 60 volunteers 17-20 yrs. The subjects were randomly assigned to Pranayam and control groups. They were divided into two groups: control (n=30), Savitri (n=30 Savitri group were practiced slow yogic breathing for three months, Paired’ test was done to compare the values within group and unpaired’ test was done to compare the values between male and female subjects. Results: In Savitri Pranayam group, the blood pressure responses to IHG were higher in males, as compared to females. The rate pressure product (RPP) also decreased during IHG 60%. A decrease in SBP and DBP was observed at the end of the study period. Briefly, a gender difference in various parameters such as MAP, QTc existed in the control group at the beginning of the study and the differences persisted at the end of three months. Conclusion: Our study reported that slow Pranayam are known to enhance parasympathetic tone, produce a highly significant decrease in oxygen consumption and psychosomatic relaxation.