The present study aimed to determine the Effectiveness of schema therapy on quality of life and psychological wellbeing of women heads of households of Hamedan. In this research was used semi-experimental methods and pretest and posttest with a control group. The target population included all women heads of households who referred to social work clinics of Hamedan province. Individuals wishing to participate in the study selected purposefully from the clinic and were replaced in experimental and control groups. The number of participants was 30 which each group contained 15 people, respectively. First, for both experimental and control groups was conducted quality of life and psychological well-being questionnaire. Then schema therapy sessions for the experimental group was done in 10 sessions but the control group did not receive any intervention. And immediately after the intervention, was conducted post-test by the quality of life and psychological well-being questionnaire for the experimental group and the control group. Finally, the data analysis was conducted by using the SPSS software version 20. The analysis of covariance showed that schema therapy increases the significantly quality of life and psychological well-being of women heads of households. Therefore, it is suggested the counselors and therapists use this method more than ever for treatment women heads of household.