To investigate benefical effects of saw palmetto (Serenoa repenes) in letrazole induced PCOS in female albino rats. Female albino wistar rats were divided in to 5 groups (n=6), Group-I considered as normal control. PCOS was induced in Group-II, Group-III, Group-IV and Group-V rats by oral administration of letrazole (1 mg/kg b.w.p.o) daily for 21 days. After Induction of PCOS Group-III, Group-IV were treated with treatment drug with saw P (medium dose 160 mg/kg and high dose 320 mg/kg) and Group-V is treated with standard drug Clomiphene Citrate (CC) respectively for 22nd to 46th day (25 days) of the study period. Physical parametrs (body weight, ovary and uterus weight), metablolic parameters (OGTT), Heart Rate (HR), Serum parameters, oxidative stress and histopathology were performed. Female albino wistar rats treated with Saw P (Group-III), Saw P (Group-IV) have shown significant decreased in body and ovarian weight, increased uterine weight, decreased total cholesterol, TG, VLDL-C and LDL-C, increased in HDL-C when results were compared with letrozole induced PCOS rats. GroupIII, Group-IV and Group-IV rats also showed significant increased in SOD, catalase and GSH when compared with PCOS induced rats. Histological results showed that saw palmetto treatment in PCOS rats resulted in welldeveloped antral follicles; normal granulosa cell layer and formation of well develop oocyte in rat ovary. From the results of the study it is concluded that saw palmetto (320 mg/kg) treatment significantly altered the letrozole induced PCOS symptoms may due to its antiandrogenic property so, it may be beneficial in PCOS.
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