Heart disease is the most costly reason for hospitalization. The purpose of this research was evaluation of the influence of teaching self care behavior for heart failure patients on economy of health in hospitals in the city of Zahedan of Iran in the year 2012.This study was quasi-experimental with a control group in the CCU and Post CCU wards of the hospitals of the city of Zahedan in 2012. The patients were randomly and conveniently placed in two groups of intervention (70 individuals) and control (70). The intervention group received an educational package and three months after discharge, both groups were evaluated using interview and phone follow-up as well as coding system (HIS), frequency of admissions and clinic visits and expenditures partaken. Next using descriptive and analytic statistical tests and the SPSS software version 18, the data was analyzed. the results showed that in the intervention group the percent of attendance to the clinic for health check up on an outpatient basis (visit and EKG) was 25% in three months before intervention and reached 41/6% at three months after intervention. Percent hospitalization in the CCU three months before intervention was 33/3% and reached 13/3% at three months after intervention and the percent change was 20%. Self care teaching program for patients with Heart failureleads to decreased hospitalization and as a result decreased treatment expenditures.