Abstract

Exploring Drug Utilization Patterns and Adverse Drug Reactions in the Management of Osteoarthritis: A Prospective Study

Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by pain, stiffness, and functional impairment, leading to significant morbidity and healthcare burden. The management of OA often involves pharmacological interventions aimed at relieving symptoms and improving quality of life. However, the utilization patterns of drugs in OA management and their associated Adverse Drug Reactions (ADRs) remain areas of ongoing research and clinical interest. In this prospective study, we aimed to explore the drug utilization patterns and identify potential adverse drug reactions among patients undergoing treatment for osteoarthritis. A diverse cohort of participants diagnosed with osteoarthritis was recruited and followed longitudinally over a specified duration. Baseline assessments captured demographic characteristics, disease severity, and previous treatment history. Participants were monitored for drug prescriptions or recommendations, including Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), analgesics, Disease-Modifying Osteoarthritis Drugs (DMOADs), corticosteroids, physical therapy, and alternative therapies. Regular monitoring was conducted to identify and assess adverse drug reactions, utilizing patient self-reporting, clinician observation, and medical records review. Data analysis focused on identifying trends in drug utilization, evaluating the frequency and severity of adverse reactions, and identifying potential risk factors associated with ADRs. The findings of this study contribute to the understanding of real-world drug utilization patterns in the management of osteoarthritis and provide insights into the safety profiles of commonly prescribed medications. By identifying potential adverse drug reactions and risk factors, this research aims to inform clinical decision-making and improve patient care and treatment outcomes in osteoarthritis management.

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