Multiple Sclerosis (MS) is a chronic and degenerative disease of the central nervous cells that upon onset of symptoms makes family faces with serious and disturbing challenges; so that experience of sudden exposure to MS leads to an unpleasant experience. The present study was conducted aims to explain exposure experiences of families with MS patients. This study was conducted by a descriptive phenomenology method in 2015. Sampling was done targeted to information saturation from 14 families of patients with MS admitted to Ayatollah Kashani Hospital. The method of the study was deep unstructured interviews. The findings from interviews were analyzed by the seven-step Colaizzi. 375 first level code, 13 second level code and 4 main concerns theme due to the unknown disease, permanent stress tolerance, confusion and family conflict and diagnosis bow were obtained from the explanations and experiences of participants including 14 people (10 women and 4 men) 19-55 years old with the education of fifth elementary to bachelor. The findings indicate that families have low awareness about the disease at early diagnosis and it leads to their severe stress and confusion about treatment, conflict, concern and family conflicts. It is hoped that findings of this research could play a leading role in the manner of families in time of exposure to the disease challenges.