Background: A career is used to describe an occupation or a profession that usually involves special training or formal education, and is considered to be a person’s lifework training. Objective: To determine the factors affecting the choice of medical basic science versus clinical science among undergraduate medical students, Qassim University. Methods: A stratified sampling technique, 204 students were enrolled in the study selected subjects was done according to the proportion of each academic year male and female medical students the, data was collected using structured online Google form due to the health emergency. Results: Most of the students, 197 (97.0%) pursue a specialization; the majority of them prefer clinical medical science 183 (94.3%). The top four preferred specialty choices were Surgery, medicine, dermatology, and pediatrics (36.4%, 12.8%, 10.3%, and 7.2%) respectively. The most popular factor in specialty choice was an interesting field. Most of the students (61.8%) are advice for choosing a specialty. There was a statistically significant association between, mother and father qualification, but there is no statistically significant between age, (Any or Both Parents are a doctor), (Given Advice by anyone). Conclusion: The majority of the student preferred clinical specialty rather than basic surgery is the most popular career choice among males and females, interest is the most important factor of selection specialty.