Logo

International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)

Abstract

Frequency of Mitochondrial DNA D-Loop Somatic Mutations in Patients with HTLV-I

Author(s): Toktam Zolfaghari, Narges Jafarzadeh, Arash Faal1, Ehsan Ghayoor Karimiani, Kamran Ghaffarzadehgan, Farid Farrokhi and Massoud Houshmand

Human T-cell Lymphotropic virus type-1 (HTLV-1) is endemic in Northeast of Iran. Still, it is unclear that genetic background has role in infection by HTLV-1. Methods: We ascertained the frequency of mitochondrial DNA (mtDNA) D-loop region nucleotide changes in 45 HTLV-1 infected individuals and 463 healthy control subjects using Sanger sequencing method. Results: Out of totally 164 identified single nucleotide polymorphisms (SNPs) among HTLV-1 patients, 89 SNPs found statistically significant in comparison to the control group (P<0.05). In this study, no deletion was identified in mtDNA D-loop region. But, for the first time a high frequency of point mutations was observed in HTLV-1 patients. Conclusion: Such nucleotide changes in HTLV-1 patients propose that these mutations may result in impaired mitochondria function directly and/or indirectly. Moreover, these variations may act as a predisposing factor along with the environmental factors, and might play an important role in pathogenesis of HTLV-1.


Card image
Subscribe Now!
Scope Categories
  • Clinical Research
  • Epidemiology
  • Oncology
  • Biomedicine
  • Dentistry
  • Medical Education
  • Physiotherapy
  • Pulmonology
  • Nephrology
  • Gynaecology
  • Dermatology
  • Dermatoepidemiology
  • Otorhinolaryngology
  • Ophthalmology
  • Sexology
  • Osteology
  • Kinesiology
  • Neuroscience
  • Haematology
  • Psychology
  • Paediatrics
  • Angiology/Vascular Medicine
  • Critical care Medicine
  • Cardiology
  • Endocrinology
  • Gastroenterology
  • Infectious Diseases and Vaccinology
  • Hepatology
  • Geriatric Medicine
  • Bariatrics
  • Pharmacy and Nursing
  • Pharmacognosy and Phytochemistry
  • Radiobiology
  • Pharmacology
  • Toxicology
  • Clinical immunology
  • Clinical and Hospital Pharmacy
  • Cell Biology
  • Genomics and Proteomics
  • Pharmacogenomics
  • Bioinformatics and Biotechnology