This study was to explore the personal history signs and symptoms, grading and types of treatmentreceived bygallbladder cancer patients.Association of Quality of life in Gallbladder cancer patients was assessed with different factors i.e., Socioeconomic status, education, stage and treatment.Quality of life was reviewed at 0,1, and 3 months in 100 patients attending general surgery and surgical oncology OPD.Method: Information was collected by quality of life questionnaire containing five parameters, physicalwell being, social wellbeing, emotional wellbeing, functional, well being, and disease specific wellbeing which was obtained from facit.org. FACT Hep Hindi(version4) was used by the permission of copy write owner. Self developed questionnaire related to symptoms, sign, stage and treatment ofpatientswere also included.Association of QOL in Gallbladder cancer patients with different factors i.e. socioeconomic status, education, stage and treatment of patient have been assessed at the time of admission.The association was assessed by dividing the patients into three groups according to their score of mean ± SD range poor, moderate and good QOL. Result:Mean age is 53 years; range is (25-80). Male/female ratio is 1:2.8, 65% patients were literate. Diet veg. & Non-veg. were 55% and 45% respectively.96% patients were married.Mean score of 100 patients in PWB, SWB, EWB, FWB, HCS, FACT-Hep score is 16.6, 19.6, 14.19, 12.88, 41.96, 103.76 respectively, which is found to be average,Most of the patients found to be in late stage with poor QOL.