Guillain-Barre Syndrome (GBS) is a serious post-infectious immune-mediated neuropathy presented with diminished reflexes and resultant weakness. Global report on GBS depicted an incidence of 1 to 4 cases per 100,000 annually and carries a high maternal risk. It is very rare among post-partum women. Aim: The study is a case of 24-year women within 2 months of the post-partum period who presented with flaccid quadriplegia diagnosed as GBS. The case is discussed in all aspects of diagnosis, treatment, and outcome.