Haemophilus influenzae Strains in Tunisian Children | Abstract

International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)


Haemophilus influenzae Strains in Tunisian Children

Author(s):Mzilem Sabrine, Smaoui Hanen and Kechrid Amel

Background: Haemophilus influenzae, a major pathogen causing respiratory tract infections and meningitis, is becoming increasingly resistant to narrow spectrum penicillin. Investigating the reasons for this resistance is challenging. Methods: The sequences of the ftsI gene, encoding the transpeptidase domain of penicillin binding protein (PBP3), were determined for 44 strains of Haemophilus influenzae with reduced susceptibility to β-lactam antibiotics. Strains, isolated from children, were analyzed for genetic relationship by pulsed-field gel electrophoresis (PFGE). Results: Sequence analysis of the ftsI gene revealed different mutations. We used this polymorphism to classify the different strains into three groups: (I (n=3), II (n=36, including H. influenzae ATCC 49247), this group was divided into four subgroups and III (n=5)). In each group various substitutions were observed. Conclusion: The increasing number of Haemophilus influenzae strains with reduced susceptibility to β-lactam due to mutations in the ftsI gene, is becoming a serious health issue in Tunisia. The resistance to β-lactam was observed in both strains that produce β-lactamase and those that do not. The level of resistance is remarkably high in our country.

Scope Categories
  • Clinical Research
  • Epidemiology
  • Oncology
  • Biomedicine
  • Dentistry
  • Medical Education
  • Physiotherapy
  • Pulmonology
  • Nephrology
  • Gynaecology
  • Dermatology
  • Dermatoepidemiology
  • Otorhinolaryngology
  • Ophthalmology
  • Sexology
  • Osteology
  • Kinesiology
  • Neuroscience
  • Haematology
  • Psychology
  • Paediatrics
  • Angiology/Vascular Medicine
  • Critical care Medicine
  • Cardiology
  • Endocrinology
  • Gastroenterology
  • Infectious Diseases and Vaccinology
  • Hepatology
  • Geriatric Medicine
  • Bariatrics
  • Pharmacy and Nursing
  • Pharmacognosy and Phytochemistry
  • Radiobiology
  • Pharmacology
  • Toxicology
  • Clinical immunology
  • Clinical and Hospital Pharmacy
  • Cell Biology
  • Genomics and Proteomics
  • Pharmacogenomics
  • Bioinformatics and Biotechnology
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