Herpes zoster (HZ) is the reactivated form of the Varicella zoster virus (VZV), the same virus responsible for chickenpox. The condition produces a striking picture, with a blistering, crusting rash confined to well demarcated areas of the body. Latency is typically life long, and Herpes Zoster is caused by viral reactivation from the latent state. The survival of Varicella Zoster Virus in human for several million years attests to its success. Present review provides an overview of the natural history, epidemiology and possible complications of varicella zoster virus along with diagnosis, prophylaxis and different treatment modalities.