Objectives: The present study aims to determine the pattern of thyroid lesions in thyroidectomy specimens received in the Pathology Department of Ibn-e Sina Hospital, Multan, Pakistan. Materials and methods: In the current research all the thyroidectomy and subtotal thyroidectomy specimen from any age, sex were included. Previously diagnosed cases with any neoplastic lesions were excluded from the research. The biopsy registers were reviewed and different lesions were categorized. Age and sex-wise variations of the lesions were noted. The study proposal was reviewed and accepted by the hospital ethical committee. Statistical analysis was done using the frequency distribution table in the Microsoft Excel Office. Results: A total of 1465 cases presented with thyroid nodule were histopathologically examined. Among these cases 1169 cases were diagnosed as simple goiter, 146 as adenoma and 86 cases were proved to be malignant tumors. These 86 malignant cases were comprised of papillary thyroid carcinoma (n=43) and follicular thyroid carcinoma (n=43). While 64 cases were categorized as “other”. Conclusion: The majority of the thyroid nodules are either non-neoplastic or benign neoplasm. Papillary and follicular thyroid carcinomas share equal prevalence in Pakistani society according to the findings of the present study.