Objective: The aim of the present study was to assess the association of Irritable bowel syndrome (IBS) with demographical and economic factors in Northern Saudi Arabia. Methodology: Data about IBS was obtained from 946 Saudi volunteers. IBS was ascertained using Rome IV criteria. Each questionnaire was filled by a medical student during an active interview. Results: The prevalence rates of IBS with continuous symptoms and intermittent symptoms were 12% and 34%, respectively. IBS was significantly predominant among females (RR (95% CI)=1.1775(1.0182 to 1.3618), p=0.0276). IBS was significantly among relatively younger adults (21-40 years) (RR (95% CI)=1.6203 (1.3425 to 1.9556), p<0.0001). Conclusion: IBS associated symptoms are prevalent in Northern Saudi Arabia. IBS was significantly associated with females’ gender and younger age.