Abstract

Identification of Microorganisms Causing Neonatal Sepsis and their Antibiotic Susceptibility

Background: Neonatal Sepsis (NS) is the existence of microorganisms that cause hemodynamic changes and other clinical effects, as well as severe morbidity and mortality, it is caused by bacteria, viruses, or fungi. Objectives: Identification of microorganisms causing NS and their antibiotic susceptibility in neonates admitted to the neonatal intensive care unit in King Faisal Medical Complex, Taif, Saudi Arabia. Materials and Methods: Prospective crosssectional study was conducted to detect NS during the period from January to August 2021. The blood samples were collected and submitted to different investigations including blood culture, CBC, and determination of inflammatory markers such as CRP. Results: This study included 110 NS cases, EOS observed in 14 (12.7%), and LOS occurred in 96 (87.3%), the male was 62 (56.3%), female 40 (36.3%) and unknown gender 8 (7.2%), the blood culture technique showed that the most commonly detected microorganisms were CoNS 28 (25.5%) E. coli 26 (23.6%) and K. pneumoniae 22 (20.0%), in addition, the antibiotic susceptibility of isolated strains showed that the Trimethoprim-Sulfamethoxazole was found to be the highest sensitive antibiotic by (83.6%), while Ampicillin was the highest resistant antibiotic by (78.1%). Conclusion: NS is a public health problem so, it is recommended that healthcare organizations design a preventive program to prevent NS specially LOS.

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