Logo

International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)

www.hxznw.com www.micaze.com www.bursaglobe.com www.enjoyantalya.com www.gzzzn.com pornofb.com pornstab.com xvideosxporn.com burdur escort bartın escort eskişehir escort izmir escort escort bursa üvey anne pornosu escort izmir
Abstract

In Vivo Study on Laxative Effect of Prunus amygdalus Oil

Author(s):Aisha Jabeen, Mirza Tasawer Baig, Shumaila Shaikh, Nausheen Alam Sarosh, Sadia Suri Kashif, Saira Shahnaz, Pireh Vengus, Hirra Soomro and Uzma Shahid

Objective: In this study, we assessed the laxative effects of Prunus amygdalus oil (PAO) in constipation model of mice. Method: The animals were divided into 6 groups and Prunus amygdalus oil was orally administered in two dose-strengths (3.0 ml/kg/day and 6.0 ml/kg/day) in mice. Group one was administered with Lactulose (30 ml/kg/day) as standard. Understandings of the possible mechanism of laxative action 2 groups of animals were pretreated with atropine (10 ml/kg/day) that moderately inhibit the laxative activity of Prunus amygdalus oil. Results: Results of our study revealed that treatment of PAO was effective in increasing the fecal number and fecal weight and this increase was very close to standard drug Lactulose, which indicate the laxative activity of oil. Those groups of animals which were previously administered with atropine partially inhibit the laxative activity of Prunus amygdalus oil, specifying that laxative action is mainly facilitated through muscarinic receptors activation and indicated the occurrence of Acetylcholine like component. Conclusion: Our study results revealed the laxative activity of PAO mediated mainly with the cholinergic pathway. This study provides a basis for beneficial use of Prunus amygdalus oil in constipation.


Card image
Subscribe Now!
Scope Categories
  • Clinical Research
  • Epidemiology
  • Oncology
  • Biomedicine
  • Dentistry
  • Medical Education
  • Physiotherapy
  • Pulmonology
  • Nephrology
  • Gynaecology
  • Dermatology
  • Dermatoepidemiology
  • Otorhinolaryngology
  • Ophthalmology
  • Sexology
  • Osteology
  • Kinesiology
  • Neuroscience
  • Haematology
  • Psychology
  • Paediatrics
  • Angiology/Vascular Medicine
  • Critical care Medicine
  • Cardiology
  • Endocrinology
  • Gastroenterology
  • Infectious Diseases and Vaccinology
  • Hepatology
  • Geriatric Medicine
  • Bariatrics
  • Pharmacy and Nursing
  • Pharmacognosy and Phytochemistry
  • Radiobiology
  • Pharmacology
  • Toxicology
  • Clinical immunology
  • Clinical and Hospital Pharmacy
  • Cell Biology
  • Genomics and Proteomics
  • Pharmacogenomics
  • Bioinformatics and Biotechnology