Introduction: Perinatal asphyxia is an essential reason for neonatal mortality and neurological morbidity. The general rate of this condition is assessed to be between 1 to 10 for every 1000 live births and is affected by the birth weight and gestational age of the infant furthermore by the neighbourhood accessibility of therapeutic assets. Methods: The underlying administration of every single such neonate comprised of putting the child under a servocontrolled radiant warmer and nursing them in the thermo-neutral range of temperature. About 41 cases accomplished for early identification of confusions and difficulties and their convenient administration. Following 72 h of birth and before 96 h of birth in the wake of getting educated composed assent from the guardians, under aseptic safety measures 3 ml blood was drawn and was assessed for blood urea (Berthelot strategy), serum creatinine (Jaffe’s test), serum electrolytes (Calorimetric technique) and urine yield was observed by applying plastic accumulation pack (minicom) and clinical state of the child was checked. Results: A sum of 1285 neonates were conceded in NICU for different issues, among them an aggregate of 90 neonates were conceded for perinatal asphyxia. A sum of 75 cases and 50 controls were chosen. The accompanying tables and figures represent the outcomes in subtle element. The outcomes got were examine blood urea and serum creatinine levels were essentially lifted in cases with renal disappointment, when contrasted with controls (P=0.001). Nevertheless, there was no distinction in electrolyte levels in both the gatherings. Conclusion: The most common perinatal danger component was MSAF (40%). In our study the commonest type of ARF in every one of the three phases of HIE was non-oliguric sort. The frequency of inherent renal disappointment in our study was 9.4%. Checking of blood urea, serum creatinine and urine yield helps in the early finding and administration of renal disappointment.