Purpose: To identify the incidence and evaluate the risk factor for the development of febrile UTI after ureteroscopic lithotripsy for ureteric stones. Materials and methods: A hospital-based prospective study. Data of 100 patients who underwent ureteroscopic lithotripsy between October 2017 and January 2018 were recorded prospectively. Mean patient age was (40.22 ± 11.354) years. Mean operative time was (25.55 ± 9.585) minutes. Follow-up duration was 1 month. Complete follow up was achieved in 86.9% of the cases. Results: Overall the stone free rate was 75%. The incidence of febrile UTI within the first month was 13%. Significant risk factors were found to be positive preoperative urine culture (53.3% vs. 5.9%, p<0.001), history of DM (46.7% vs. 7.1%, p<0.001), presence of renal stone (46.2% vs. 8.0%, p<0.001) and female gender (60.9% vs. 27.6%, p=0.016). Conclusion: The incidence of febrile UTI was higher than recorded in other studies. A number of significant risk factors were found to be associated with the development of febrile UTI. Judicious measures should be taken both pre and postoperatively in order to eliminate or at least minimize the risk of developing febrile UTI after ureteroscopy.